AUTHOR=Rao Shanshan , Xu Tao , Xia Yu , Zhang Hongfeng 

TITLE=Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB

JOURNAL=Frontiers in Microbiology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.573844

DOI=10.3389/fmicb.2020.573844

ISSN=1664-302X

ABSTRACT=<p>Phagosome- and xenophagosome-lysosome systems play a critical role in the defense of pathogenic bacteria, such as <italic>Salmonella</italic> and <italic>S. aureus</italic>, in macrophages. A great part of the bacteria escapes from the digestion and can survive through some mechanisms that are still poorly understood and which require further exploration. Here we identified that <italic>Salmonella</italic> inhibited the expression and activation of TFEB to blunt the functions of lysosomes and defense of clearance by activating caspase-1. The expression and activation of TFEB were enhanced early under the infection of <italic>S. aureus</italic>, which was followed by shrinkage to weaken lysosomal functions due to the delayed activation of ERK, mTOR, and STAT3. Thus, we have identified novel escape mechanisms for <italic>Salmonella</italic> and <italic>S. aureus</italic> to deepen and strengthen our strategies fighting with pathogens.</p>