AUTHOR=Batista Viviane Lima , da Silva Tales Fernando , de Jesus Luís Cláudio Lima , Coelho-Rocha Nina Dias , Barroso Fernanda Alvarenga Lima , Tavares Laisa Macedo , Azevedo Vasco , Mancha-Agresti Pamela , Drumond Mariana Martins TITLE=Probiotics, Prebiotics, Synbiotics, and Paraprobiotics as a Therapeutic Alternative for Intestinal Mucositis JOURNAL=Frontiers in Microbiology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.544490 DOI=10.3389/fmicb.2020.544490 ISSN=1664-302X ABSTRACT=

Intestinal mucositis, a cytotoxic side effect of the antineoplastic drug 5-fluorouracil (5-FU), is characterized by ulceration, inflammation, diarrhea, and intense abdominal pain, making it an important issue for clinical medicine. Given the seriousness of the problem, therapeutic alternatives have been sought as a means to ameliorate, prevent, and treat this condition. Among the alternatives available to address this side effect of treatment with 5-FU, the most promising has been the use of probiotics, prebiotics, synbiotics, and paraprobiotics. This review addresses the administration of these “biotics” as a therapeutic alternative for intestinal mucositis caused by 5-FU. It describes the effects and benefits related to their use as well as their potential for patient care.