AUTHOR=Zhang Hui , Zhang Ge , Zhang Jingjia , Duan Simeng , Kang Yue , Yang Qiwen , Xu Yingchun 

TITLE=Antimicrobial Activity of Colistin Against Contemporary (2015 – 2017) P. aeruginosa and A. baumannii Isolates From a Chinese Surveillance Program

JOURNAL=Frontiers in Microbiology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.01966

DOI=10.3389/fmicb.2020.01966

ISSN=1664-302X

ABSTRACT=<sec><title>Objective</title><p>To investigate the incidence and susceptibilities of non-fermenting bacteria isolates from Chinese respiratory (RTI), intra-abdominal (IAI) and urinary tract (UTI) infections to antimicrobial agents between 2015 and 2017.</p></sec><sec><title>Methods</title><p>In total, 3,246 non-fermentative bacteria were collected from 21 hospitals and 9 hospital departments across 7 regions of China. A central testing laboratory was employed to determine antimicrobial susceptibilities using appropriate standards of interpretation.</p></sec><sec><title>Results</title><p>The majority of the isolates were <italic>Acinetobacter baumannii</italic> (<italic>n</italic> = 1,360, 41.9%) and <italic>Pseudomonas aeruginosa</italic> (<italic>n</italic> = 1,341, 41.3%). Overall multidrug resistance (MDR) and carbapenem resistance (CR) rates of <italic>Acinetobacter baumannii</italic> were 80.1 and 78.7% with MDR and CR rates in RTIs, IAIs, and UTIs of 82.0 and 81.0%, 82.6 and 81.0% as well as 53.1 and 46.9%. Overall MDR and CR rates of <italic>Pseudomonas aeruginosa</italic> isolates were 36.2 and 38.9% with 41.8 and 44.3%, 29.3 and 36.1% as well as 24.2 and 20.2% MDR and CR rates in RTIs, IAIs, and UTIs. Overall susceptibility rates to imipenem, meropenem, amikacin, ciprofloxacin, cefepime and piperacillin-tazobactam were 21.1, 21.3, 33.0, 18.4, 19.2, and 19.6% for <italic>Acinetobacter baumannii</italic> and 56.5, 58.5, 88.4, 63.1, 63.1, and 55.63% for <italic>Pseudomonas aeruginosa</italic> isolates, whereas for colistin they were 95.7 and 94.6%, respectively. In all departments and regions of China, susceptibility rates of <italic>Pseudomonas aeruginosa</italic> and <italic>Acinetobacter baumannii</italic> isolates to colistin were constantly above 80%.</p></sec><sec><title>Conclusion</title><p>Due to the high MDR and CR rates for <italic>Pseudomonas aeruginosa</italic> and <italic>Acinetobacter baumannii</italic>, isolates obtained from RTIs, IAIs, and UTIs only maintained high susceptibility rates to colistin between 2015 and 2017.</p></sec>