AUTHOR=Santos Igor de Andrade , Grosche Victória Riquena , Bergamini Fernando Rodrigues Goulart , Sabino-Silva Robinson , Jardim Ana Carolina Gomes 

TITLE=Antivirals Against Coronaviruses: Candidate Drugs for SARS-CoV-2 Treatment?

JOURNAL=Frontiers in Microbiology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.01818

DOI=10.3389/fmicb.2020.01818

ISSN=1664-302X

ABSTRACT=<p>Coronaviruses (CoVs) are a group of viruses from the family <italic>Coronaviridae</italic> that can infect humans and animals, causing mild to severe diseases. The ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a global threat, urging the development of new therapeutic strategies. Here we present a selection of relevant compounds that have been described from 2005 until now as having <italic>in vitro</italic> and/or <italic>in vivo</italic> antiviral activities against human and/or animal CoVs. We also present compounds that have reached clinical trials as well as further discussing the potentiality of other molecules for application in (re)emergent CoVs outbreaks. Finally, through rationalization of the data presented herein, we wish to encourage further research encompassing these compounds as potential SARS-CoV-2 drug candidates.</p>