AUTHOR=Li Xinhong , Wang Mingshu , Cheng Anchun , Wen Xingjian , Ou Xumin , Mao Sai , Gao Qun , Sun Di , Jia Renyong , Yang Qiao , Wu Ying , Zhu Dekang , Zhao Xinxin , Chen Shun , Liu Mafeng , Zhang Shaqiu , Liu Yunya , Yu Yanling , Zhang Ling , Tian Bin , Pan Leichang , Chen Xiaoyue 

TITLE=Enterovirus Replication Organelles and Inhibitors of Their Formation

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.01817

DOI=10.3389/fmicb.2020.01817

ISSN=1664-302X

ABSTRACT=Enteroviral replication reorganizes the cellular membrane. In a concerted fashion, viral proteins and host factors generate unique organelle-like structures called replication organelles (ROs) to replicate their viral genomes. ROs promote efficient viral genome replication, allow spatiotemporal coordination of the steps of the viral replication cycle, and protect viral RNA from host immune responses. Combined use of ultrastructural and functional research has greatly increased our understanding of the architecture and biogenesis of ROs. Here, we review the recent findings concerning the role, architecture, biogenesis, formation mechanism, and inhibitors of enterovirus ROs.