AUTHOR=Eix Emily F. , Nett Jeniel E. 

TITLE=How Biofilm Growth Affects Candida-Host Interactions

JOURNAL=Frontiers in Microbiology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.01437

DOI=10.3389/fmicb.2020.01437

ISSN=1664-302X

ABSTRACT=<p><italic>Candida</italic> spp. proliferate as surface-associated biofilms in a variety of clinical niches. These biofilms can be extremely difficult to eradicate in healthcare settings. Cells within biofilm communities grow as aggregates and produce a protective extracellular matrix, properties that impact the ability of the host to respond to infection. Cells that disperse from biofilms display a phenotype of enhanced pathogenicity. In this review, we highlight host-biofilm interactions for <italic>Candida</italic>, focusing on how biofilm formation influences innate immune responses.</p>