AUTHOR=Rehman Saif Ur , Yang Lu-Jia , Zhang Ya-Hui , Wu Jing-Shuai , Shi Ting , Haider Waqas , Shao Chang-Lun , Wang Chang-Yun 

TITLE=Sorbicillinoid Derivatives From Sponge-Derived Fungus Trichoderma reesei (HN-2016-018)

JOURNAL=Frontiers in Microbiology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.01334

DOI=10.3389/fmicb.2020.01334

ISSN=1664-302X

ABSTRACT=<p>Six new sorbicillinoids, trichoreeseione A (<bold>1</bold>) and B (<bold>2</bold>), trichodermolide B (<bold>3</bold>), 13-hydroxy<bold>-</bold>trichodermolide (<bold>4</bold>), 24-hydroxy-trichodimerol (<bold>5</bold>), 15-hydroxy<bold>-</bold>bisvertinol (<bold>7</bold>), together with three known analogs, trichodimerol (<bold>6</bold>), 24-hydroxy<bold>-</bold>bisvertinol (<bold>8</bold>), and bisvertinol (<bold>9</bold>), were isolated from the sponge-derived fungus <italic>Trichoderma reesei</italic> (HN-2016-018). Their structures including absolute configurations were elucidated by analysis of NMR, MS data, and calculated ECD spectra. Compounds <bold>1</bold> and <bold>2</bold> with a characteristic naphthalene-trione ring were firstly reported in sorbicillinoid family. Compounds <bold>3</bold> and <bold>4</bold> were two rare sorbicillinoids containing a unique bicycle [3.2.1] lactone skeleton, while <bold>3</bold> with a propan-2-one moiety was also recorded first time in this family. Compound <bold>5</bold> displayed cytotoxic activity against A549, MCF-7, and HCT116 cell lines with the IC<sub>50</sub> values of 5.1, 9.5, and 13.7 μM, respectively.</p>