AUTHOR=Ayadi Rania , Sitterlé Emilie , d’Enfert Christophe , Dannaoui Eric , Bougnoux Marie-Elisabeth 

TITLE=Candida albicans and Candida dubliniensis Show Different Trailing Effect Patterns When Exposed to Echinocandins and Azoles

JOURNAL=Frontiers in Microbiology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.01286

DOI=10.3389/fmicb.2020.01286

ISSN=1664-302X

ABSTRACT=<p>When <italic>Candida albicans</italic> and <italic>Candida dubliniensis</italic> isolates were tested for susceptibility to fluconazole and echinocandins using either EUCAST or Etest methods, differential patterns of growth were observed, independently of the methods used. For <italic>C. albicans</italic>, a trailing phenomenon (incomplete growth inhibition at supra-MICs) was observed with fluconazole in 90% and 93.3% for EUCAST and Etest, respectively, but not with echinocandins (&lt;7% for EUCAST and 0% for Etest). In contrast, for <italic>C. dubliniensis</italic>, a trailing phenomenon was very rarely observed with fluconazole (20% for EUCAST and 0% for Etest), while the opposite pattern was observed with echinocandins (&gt;50% for EUCAST and &gt;86% for Etest). This suggests that the pathways involved in the trailing effect might be different between these two related species. Furthermore, clinical microbiologists must be aware of these species-specific patterns for a reliable MIC determination.</p>