AUTHOR=Xu Yu , Wang Ning , Tan Hor-Yue , Li Sha , Zhang Cheng , Feng Yibin 

TITLE=Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

JOURNAL=Frontiers in Microbiology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.00219

DOI=10.3389/fmicb.2020.00219

ISSN=1664-302X

ABSTRACT=<p>Obesity and its metabolic syndrome, including liver disorders and type 2 diabetes, are a worldwide epidemic and are intimately linked to diet. The gut microbiota interaction has been pointed to as a hot topic of research in the treatment of obesity and related metabolic diseases by influencing energy metabolism and the immune system. In terms of the novel beneficial microbes identified, <italic>Akkermansia muciniphila</italic> (<italic>A. muciniphila</italic>) colonizes the mucosa layer of the gut and modulates basal metabolism. <italic>A. muciniphila</italic> is consistently correlated with obesity. The causal beneficial impact of <italic>A. muciniphila</italic> treatment on obesity is coming to light, having been proved by a variety of animal models and human studies. <italic>A. muciniphila</italic> has been characterized as a beneficial player in body metabolism and has great prospects for treatments of the metabolic disorders associated with obesity, as well as being considered for next-generation therapeutic agents. This paper aimed to investigate the basic mechanism underlying the relation of <italic>A. muciniphila</italic> to obesity and its host interactions, as identified in recent discoveries, facilitating the establishment of the causal relationship in <italic>A. muciniphila</italic>-associated therapeutic supplement in humans.</p>