AUTHOR=Sun Qiaoling , Wang Hanyu , Shu Lingbin , Dong Ning , Yang Fan , Zhou Hongwei , Chen Sheng , Zhang Rong 

TITLE=Leclercia adecarboxylata From Human Gut Flora Carries mcr-4.3 and blaIMP-4-Bearing Plasmids

JOURNAL=Frontiers in Microbiology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.02805

DOI=10.3389/fmicb.2019.02805

ISSN=1664-302X

ABSTRACT=<p>A clinical <italic>Leclercia adecarboxylata</italic> strain harboring the <italic>mcr-4.3</italic> and <italic>bla</italic><sub>IMP-4</sub> genes was isolated from active rectal screening of carbapenem-resistant Enterobacteriaceae (CRE) in a patient. The isolate was found to harbor seven plasmids, including a 94,635 bp <italic>bla</italic><sub>IMP-4</sub>-bearing IncN plasmid and a 9,782 bp <italic>mcr-4.3</italic>-bearing ColE10-type plasmid. The isolate was susceptible to colistin despite carrying the <italic>mcr-4.3</italic> gene, suggesting that this MCR-4 variant may not be functional. Carriage of antibiotic resistance genes in human gut <italic>L. adecarboxylata</italic> strain suggests that close surveillance of resistance strains in the human gut flora should be included as a routine clinical practice to prevent occurrence of infections, especially among immunocompromised patients.</p>