AUTHOR=Vrabl Pamela , Schinagl Christoph W. , Artmann Desirée J. , Heiss Benedikt , Burgstaller Wolfgang TITLE=Fungal Growth in Batch Culture – What We Could Benefit If We Start Looking Closer JOURNAL=Frontiers in Microbiology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.02391 DOI=10.3389/fmicb.2019.02391 ISSN=1664-302X ABSTRACT=
Since filamentous fungi rapidly adjust their metabolic properties to environmental changes, a rigorous standardization and characterization of cultivation conditions is necessary to obtain meaningful and reproducible results. In batch cultures, which are commonly characterized according to the classical growth curve in textbooks (i.e., lag, exponential, stationary, and declining phase), this is of special difficulty. Although various studies in literature report atypically shaped growth curves of filamentous fungi in batch culture, systematic investigations on this topic are scarce and deviations are barely mentioned in textbooks. Summarizing approximately a decade of observations of growth characteristics from bioreactor batch grown filamentous fungi – in particular two strains (CBS123.823 and CBS123.824) of