AUTHOR=Thompson Aiysha , Griffiths James S. , Walker Louise , da Fonseca Diogo M. , Lee Keunsook K. , Taylor Philip R. , Gow Neil A. R. , Orr Selinda J. 

TITLE=Dependence on Dectin-1 Varies With Multiple Candida Species

JOURNAL=Frontiers in Microbiology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.01800

DOI=10.3389/fmicb.2019.01800

ISSN=1664-302X

ABSTRACT=<p>Four <italic>Candida</italic> spp. (<italic>albicans</italic>, <italic>glabrata</italic>, <italic>tropicalis</italic>, <italic>parapsilosis</italic>) cause &gt;95% of invasive <italic>Candida</italic> infections. <italic>C. albicans</italic> elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs). The CLR, Dectin-1 is important for host immunity to <italic>C. albicans</italic> and <italic>C. glabrata</italic>, however, whether Dectin-1 is important for host defense against <italic>C. tropicalis</italic> or <italic>C. parapsilosis</italic> is unknown. Therefore, we compared the involvement of Dectin-1 in response to these four diverse <italic>Candida</italic> spp. We found that Dectin-1 mediates innate cytokine responses to these <italic>Candida</italic> spp. in a species- and cell-dependent manner. Dectin-1 KO mice succumbed to infection with highly virulent <italic>C. albicans</italic> while they mostly survived infection with less virulent <italic>Candida</italic> spp. However, Dectin-1 KO mice displayed increased fungal burden following infection with each <italic>Candida</italic> spp. Additionally, T cells from Dectin-1 KO mice displayed enhanced effector functions likely due to the inability of Dectin-1 KO mice to clear the infections. Together, these data indicate that Dectin-1 is important for host defense to multiple <italic>Candida</italic> spp., although the specific roles for Dectin-1 varies with different <italic>Candida</italic> spp.</p>