AUTHOR=Wang Yaonan , Cai Yuan , Zhang Jian , Liu Dong , Gong Xiao , Pan Zhiming , Geng Shizhong , Jiao Xin’an 

TITLE=Controversy Surrounding the Function of SpiC Protein in Salmonella: An Overview

JOURNAL=Frontiers in Microbiology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.01784

DOI=10.3389/fmicb.2019.01784

ISSN=1664-302X

ABSTRACT=<p><italic>Salmonella</italic> is an important pathogenic microorganism that can infect humans and animals and has been studied globally as a model microorganism for its pathogenesis. The SpiC protein of T3SS2 is a significant factor that has been studied for almost 20 years, but to date, the function/effect of SpiC in the pathogenesis of <italic>Salmonella</italic> has not been completely understood. There is controversy over the functions of SpiC protein in the literature. Thus, an overview of the literature on SpiC protein is provided here which highlights expression features of SpiC protein and its various functions and effect.</p>