AUTHOR=Klassen Jonathan L. , Lee Seoung Rak , Poulsen Michael , Beemelmanns Christine , Kim Ki Hyun 

TITLE=Efomycins K and L From a Termite-Associated Streptomyces sp. M56 and Their Putative Biosynthetic Origin

JOURNAL=Frontiers in Microbiology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.01739

DOI=10.3389/fmicb.2019.01739

ISSN=1664-302X

ABSTRACT=<p>Two new elaiophylin derivatives, efomycins K (<bold>1</bold>) and L (<bold>2</bold>), and five known elaiophylin derivatives (<bold>3–7</bold>) were isolated from the termite-associated <italic>Streptomyces</italic> sp. M56. The structures were determined by 1D and 2D NMR and HR-ESIMS analyses and comparative CD spectroscopy. The putative gene cluster responsible for the production of the elaiophylin and efomycin derivatives was identified based on significant homology to related clusters. Phylogenetic analysis of gene cluster domains was used to provide a biosynthetic rational for these new derivatives and to demonstrate how a single biosynthetic pathway can produce diverse structures.</p>