AUTHOR=Zhang Zhenlu , He Guijuan , Filipowicz Natalie A. , Randall Glenn , Belov George A. , Kopek Benjamin G. , Wang Xiaofeng 

TITLE=Host Lipids in Positive-Strand RNA Virus Genome Replication

JOURNAL=Frontiers in Microbiology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.00286

DOI=10.3389/fmicb.2019.00286

ISSN=1664-302X

ABSTRACT=<p>Membrane association is a hallmark of the genome replication of positive-strand RNA viruses [(+)RNA viruses]. All well-studied (+)RNA viruses remodel host membranes and lipid metabolism through orchestrated virus-host interactions to create a suitable microenvironment to survive and thrive in host cells. Recent research has shown that host lipids, as major components of cellular membranes, play key roles in the replication of multiple (+)RNA viruses. This review focuses on how (+)RNA viruses manipulate host lipid synthesis and metabolism to facilitate their genomic RNA replication, and how interference with the cellular lipid metabolism affects viral replication.</p>