AUTHOR=Wang Xiaoming , Wang Yao , Zhou Ying , Wang Zheng , Wang Yang , Zhang Suxia , Shen Zhangqi 

TITLE=Emergence of Colistin Resistance Gene mcr-8 and Its Variant in Raoultella ornithinolytica

JOURNAL=Frontiers in Microbiology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.00228

DOI=10.3389/fmicb.2019.00228

ISSN=1664-302X

ABSTRACT=<p>Recently, a novel mobile colistin resistance gene, <italic>mcr-8</italic>, was identified in <italic>Klebsiella pneumoniae</italic>. Here, we report the identification of <italic>mcr-8</italic> and its variant, <italic>mcr-8.4</italic>, in <italic>Raoultella ornithinolytica</italic> isolates which also belong to Enterobacteriaceae family. The <italic>mcr-8</italic> gene was located on transferrable plasmids with difference sizes. Notably, the transferability of <italic>mcr-8</italic>-carrying plasmids was enhanced once they entered into <italic>Escherichia coli</italic> hosts and multiple β-lactamase genes could co-transfer with <italic>mcr-8</italic>. These findings expand our knowledge of <italic>mcr-8</italic>-carrying bacterial species.</p>