AUTHOR=Wang Xiaoming , Wang Yao , Zhou Ying , Wang Zheng , Wang Yang , Zhang Suxia , Shen Zhangqi
TITLE=Emergence of Colistin Resistance Gene mcr-8 and Its Variant in Raoultella ornithinolytica
JOURNAL=Frontiers in Microbiology
VOLUME=10
YEAR=2019
URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.00228
DOI=10.3389/fmicb.2019.00228
ISSN=1664-302X
ABSTRACT=
Recently, a novel mobile colistin resistance gene, mcr-8, was identified in Klebsiella pneumoniae. Here, we report the identification of mcr-8 and its variant, mcr-8.4, in Raoultella ornithinolytica isolates which also belong to Enterobacteriaceae family. The mcr-8 gene was located on transferrable plasmids with difference sizes. Notably, the transferability of mcr-8-carrying plasmids was enhanced once they entered into Escherichia coli hosts and multiple β-lactamase genes could co-transfer with mcr-8. These findings expand our knowledge of mcr-8-carrying bacterial species.