AUTHOR=Zeng Lijun , Zhan Zhe , Hu Lingfei , Jiang Xiaoyuan , Zhang Yanjun , Feng Jiao , Gao Bo , Zhao Yuee , Yang Wenhui , Yang Huiying , Yin Zhe , Zhou Dongsheng 

TITLE=Genetic Characterization of a blaVIM–24-Carrying IncP-7β Plasmid p1160-VIM and a blaVIM–4-Harboring Integrative and Conjugative Element Tn6413 From Clinical Pseudomonas aeruginosa

JOURNAL=Frontiers in Microbiology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.00213

DOI=10.3389/fmicb.2019.00213

ISSN=1664-302X

ABSTRACT=<p>This study presents three novel integrons In1394, In1395, and In1443, three novel unit transposons Tn<italic>6392</italic>, Tn<italic>6393</italic>, and Tn<italic>6403</italic>, one novel conjugative element (ICE) Tn<italic>6413</italic>, and the first sequenced IncP-7 resistance plasmid p1160-VIM from clinical <italic>Pseudomonas aeruginosa</italic>. Detailed sequence comparison of p1160-VIM (carrying Tn<italic>6392</italic> and Tn<italic>6393</italic>) and Tn<italic>6413</italic> (carrying Tn<italic>6403</italic>) with related elements were performed. Tn<italic>6392</italic>, Tn<italic>6393</italic>, and Tn<italic>6403</italic> were generated from integration of In1394 (carrying <italic>bla</italic><sub>VIM–24</sub>), In1395 and In1443 (carrying <italic>bla</italic><sub>VIM–4</sub>) into prototype Tn<italic>3</italic>-family unit transposons Tn<italic>5563</italic>, Tn<italic>1403</italic>, and Tn<italic>6346</italic>, respectively. To the best of our knowledge, this is the first report of a <italic>bla</italic><sub>VIM–24</sub>-carrying <italic>P. aeruginosa</italic> isolate.</p>