AUTHOR=Górski Andrzej , Bollyky Paul L. , Przybylski Maciej , Borysowski Jan , Międzybrodzki Ryszard , Jończyk-Matysiak Ewa , Weber-Dąbrowska Beata 

TITLE=Perspectives of Phage Therapy in Non-bacterial Infections

JOURNAL=Frontiers in Microbiology

VOLUME=9

YEAR=2019

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.03306

DOI=10.3389/fmicb.2018.03306

ISSN=1664-302X

ABSTRACT=<p>While the true value of phage therapy (PT) in human bacterial infections still awaits formal confirmation by clinical trials, new data have been accumulating indicating that in the future PT may be applied in the treatment of non-bacterial infections. Thus, “phage guests” may interact with eukaryotic cells and such interactions with cells of the immune system may protect human health (<xref ref-type="bibr" rid="B24">Guglielmi, 2017</xref>) and cause clinically useful immunomodulatory and anti-inflammatory effects when administered for therapeutic purposes (<xref ref-type="bibr" rid="B17">Górski et al., 2017</xref>; <xref ref-type="bibr" rid="B71">Van Belleghem et al., 2017</xref>). Recently, a vision of how these effects could translate into advances in novel means of therapy in a variety of human pathologies secondary to immune disturbances and allergy was presented (<xref ref-type="bibr" rid="B18">Górski et al., 2018a</xref>). In this article we present what is currently known about anti-microbial effects of phage which are not directly related to their antibacterial action and how these findings could be applied in the future in treatment of viral and fungal infections.</p>