AUTHOR=Zhang Jie , Sun Jian , Chen Xiyue , Nie Cunxi , Zhao Jinbiao , Guan Wenyi , Lei Lihui , He Ting , Chen Yiqiang , Johnston Lee J. , Zhao Jinshan , Ma Xi 

TITLE=Combination of Clostridium butyricum and Corn Bran Optimized Intestinal Microbial Fermentation Using a Weaned Pig Model

JOURNAL=Frontiers in Microbiology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.03091

DOI=10.3389/fmicb.2018.03091

ISSN=1664-302X

ABSTRACT=<p>Experimental manipulation of the intestinal microbiota influences health of the host and is a common application for synbiotics. Here <italic>Clostridium butyricum</italic> (<italic>C. butyricum</italic>, <italic>C.B</italic>) combined with corn bran (<italic>C.B</italic> + Bran) was taken as the synbiotics application in a waned pig model to investigate its regulation of intestinal health over 28 days postweaning. Growth performance, fecal short chain fatty acids (SCFAs) and bacterial community were evaluated at day 14 and day 28 of the trial. Although the <italic>C.B</italic> + Bran treatment has no significant effects on growth performance (<italic>P</italic> &gt; 0.05), it optimized the composition of intestinal bacteria, mainly represented by increased acetate-producing bacteria and decreased pathogens. Microbial fermentation in the intestine showed a shift from low acetate and isovalerate production on day 14 to enhanced acetate production on day 28 in the <italic>C.B</italic> + Bran treatment. Thus, <italic>C.B</italic> and corn bran promoted intestinal microbial fermentation and optimized the microbial community for pigs at an early age. These findings provide perspectives on the advantages of synbiotics as a new approach for effective utilization of corn barn.</p>