AUTHOR=Lin Xiangna , Xia Yongjun , Wang Guangqiang , Yang Yijin , Xiong Zhiqiang , Lv Fang , Zhou Wei , Ai Lianzhong 

TITLE=Lactic Acid Bacteria With Antioxidant Activities Alleviating Oxidized Oil Induced Hepatic Injury in Mice

JOURNAL=Frontiers in Microbiology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.02684

DOI=10.3389/fmicb.2018.02684

ISSN=1664-302X

ABSTRACT=<p>In order to screening new Lactic acid bacteria (LAB) strains to alleviating liver injury induced by oxidized oil, we isolated and screened LAB from Chinese fermented foods. <italic>Lactobacillus plantarum</italic> AR113, <italic>Pediococcus pentosaceus</italic> AR243, and <italic>Lactobacillus plantarum</italic> AR501 showed higher scavenging activity of α, α-Diphenyl-β-Picrylhydrazyl (DPPH) free radical and hydrogen radical, stronger inhibition of lipid peroxidation, and better protective effect on yeast cells <italic>in vitro</italic>. <italic>In vivo</italic>, oral administration of <italic>L. plantarum</italic> AR501 improved the antioxidant status of injury mice induced by oxidized oil including decreasing lipid peroxidation, recovering activities of antioxidant enzymes. Meanwhile, the gene expression of Nuclear factor erythroid 2-related factor 2 (Nrf2) of <italic>L. plantarum</italic> AR501 group was markedly elevated, and several antioxidant genes such as glutathione S-transferase (GSTO1), heme oxygenase-1 (HO-1), Glutamate cysteine ligase (GCL), and NAD(P)H:quinone oxidoreductase-l (NQO1) were subsequently up regulated in mice liver. Therefore, <italic>L. plantarum</italic> AR501 could be considered as potential candidates for production of functional foods that can alleviate the oxidative damage induced by oxidized oil.</p>