AUTHOR=Wang Chonglong , Liwei Mudanguli , Park Ji-Bin , Jeong Seong-Hee , Wei Gongyuan , Wang Yujun , Kim Seon-Won 

TITLE=Microbial Platform for Terpenoid Production: Escherichia coli and Yeast

JOURNAL=Frontiers in Microbiology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.02460

DOI=10.3389/fmicb.2018.02460

ISSN=1664-302X

ABSTRACT=<p>Terpenoids, also called isoprenoids, are a large and highly diverse family of natural products with important medical and industrial properties. However, a limited production of terpenoids from natural resources constrains their use of either bulk commodity products or high valuable products. Microbial production of terpenoids from <italic>Escherichia coli</italic> and yeasts provides a promising alternative owing to available genetic tools in pathway engineering and genome editing, and a comprehensive understanding of their metabolisms. This review summarizes recent progresses in engineering of industrial model strains, <italic>E. coli</italic> and yeasts, for terpenoids production. With advances of synthetic biology and systems biology, both strains are expected to present the great potential as a platform of terpenoid synthesis.</p>