AUTHOR=Xu Honghai , Wei Yuanyuan , Ma Hongqiu , Liu Yanyan , Zhang Yalong , Hu Lifen , Li Jiabin TITLE=Alterations of Gut Microbiome in the Patients With Severe Fever With Thrombocytopenia Syndrome JOURNAL=Frontiers in Microbiology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.02315 DOI=10.3389/fmicb.2018.02315 ISSN=1664-302X ABSTRACT=
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by SFTS virus, and the number of SFTS cases increased year by year in China. Previous studies had indicated that gut microbiome closely associated with human health and diseases, including infection diseases, liver diseases, gastrointestinal diseases and metabolic diseases. The aim of this study is to investigate the alterations and involvements of gut microbial in SFTS patients. We compared the gut microbiome of 26 SFTS patients between 20 health controls using the Illumina MiSeq sequencing platform. Reduced gut microbiota diversity and dramatic shifts of fecal microbial composition in SFTS patients were observed compared with health controls. In the intestinal microbial of SFTS patients, the