AUTHOR=Wang Guanhao , Liu Qing , Guo Liang , Zeng Haijuan , Ding Chengchao , Zhang Wentong , Xu Dongpo , Wang Xiang , Qiu Jingxuan , Dong Qingli , Fan Ziquan , Zhang Qi , Pan Jing TITLE=Gut Microbiota and Relevant Metabolites Analysis in Alcohol Dependent Mice JOURNAL=Frontiers in Microbiology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.01874 DOI=10.3389/fmicb.2018.01874 ISSN=1664-302X ABSTRACT=
Alcohol abuse is a major public health crisis. Relative evidences supported that the gut microbiota (GM) played an important role in central nervous system (CNS) function, and the composition of them had changed after alcohol drinking. We sought to explore the changes of GM in alcohol dependence. In our study, the GM of mice with alcohol administration was detected through analyzed 16S rRNA gene sequencing and the fecal metabolites were analyzed by LC-MS. The microbial diversity was significantly higher in the alcohol administration group, the abundance of phylum