AUTHOR=Knöppel Anna , Knopp Michael , Albrecht Lisa M. , Lundin Erik , Lustig Ulrika , Näsvall Joakim , Andersson Dan I. TITLE=Genetic Adaptation to Growth Under Laboratory Conditions in Escherichia coli and Salmonella enterica JOURNAL=Frontiers in Microbiology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.00756 DOI=10.3389/fmicb.2018.00756 ISSN=1664-302X ABSTRACT=
Experimental evolution under controlled laboratory conditions is becoming increasingly important to address various evolutionary questions, including, for example, the dynamics and mechanisms of genetic adaptation to different growth and stress conditions. In such experiments, mutations typically appear that increase the fitness under the conditions tested (medium adaptation), but that are not necessarily of interest for the specific research question. Here, we have identified mutations that appeared during serial passage of