AUTHOR=Rauf Mohd A. , Zubair Swaleha , Ateeq Hira , Dabeer Khadija , Pachauri Subodh , Ajmal Mohd , Owais Mohammad 

TITLE=Synergistic Effect of Diallyl Sulfide With Zinc Oxide Nanorods: A Novel and Effective Approach for Treatment of Acute Dermatitis in Model Animals

JOURNAL=Frontiers in Microbiology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2018.00586

DOI=10.3389/fmicb.2018.00586

ISSN=1664-302X

ABSTRACT=<p>Besides inciting persistent and recurrent nosocomial afflictions, <italic>Staphylococcus aureus</italic> (<italic>S</italic>. <italic>aureus</italic>), a biofilm forming pathogen, poses an increased risk of several skin as well as respiratory tract infections as well. Emerging antimicrobial resistance trend asks to search for an alternate non-antibiotic based option to combat <italic>S. aureus</italic> pathogen. In the present study, we evaluated synergistic antimicrobial potential of Zinc oxide nanorods (ZnO-NRs) and diallyl sulphide (DAS) emulsion against methicillin resistant <italic>Staphylococcus aureus</italic> (MRSA). The antimicrobial assessment study suggests that the ZnO-NR and DAS emulsion effectively suppressed both sensitive <italic>S. aureus</italic> as well as MRSA isolates. The combination treatment showed enhanced activity even at a lower concentration as compared to the single treatment based on ZnO-NRs and DAS emulsion alone. The ZnO-NRs-DAS combination showed significant inhibition of MRSA biofilm as well. The data suggest that a combination therapy, comprising of ZnO-NRs and DAS emulsion, successfully treated experimental dermatitis infection caused by MRSA in mice model.</p>