AUTHOR=Vallinoto Antonio C. R. , Santana Bárbara B. , Queiroz Maria A. F. , da Silva Andrea N. M. R. , Cayres-Vallinoto Izaura M. V. , da Costa Carlos A. , de Sousa Maisa S. , Ishak Ricardo 

TITLE=Family Aggregation of HTLV-1 Infection Associated with FAS -670A/G Polymorphism: A Case Report

JOURNAL=Frontiers in Microbiology

VOLUME=8

YEAR=2018

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.02685

DOI=10.3389/fmicb.2017.02685

ISSN=1664-302X

ABSTRACT=<p>Human T-lymphotropic virus 1 (HTLV-1) infection has been associated with ATL and inflammatory diseases but remains a neglected health problem. HTLV-1 associated diseases were originally described as sporadic entities, but family aggregations have been reported. Viral, genetic, immunological and behavioral factors were used to explain family clusters, but until now a clear explanation remains uncertain. In the present study we report, for the first time, a family cluster of diseased persons presenting the infection across three generations associated with FAS -670A/G polymorphism.</p>