AUTHOR=Oliveira Alberto , Oliveira Leticia C. , Aburjaile Flavia , Benevides Leandro , Tiwari Sandeep , Jamal Syed B. , Silva Arthur , Figueiredo Henrique C. P. , Ghosh Preetam , Portela Ricardo W. , De Carvalho Azevedo Vasco A. , Wattam Alice R. 

TITLE=Insight of Genus Corynebacterium: Ascertaining the Role of Pathogenic and Non-pathogenic Species

JOURNAL=Frontiers in Microbiology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.01937

DOI=10.3389/fmicb.2017.01937

ISSN=1664-302X

ABSTRACT=<p>This review gathers recent information about genomic and transcriptomic studies in the <italic>Corynebacterium</italic> genus, exploring, for example, prediction of pathogenicity islands and stress response in different pathogenic and non-pathogenic species. In addition, is described several phylogeny studies to <italic>Corynebacterium</italic>, exploring since the identification of species until biological speciation in one species belonging to the genus <italic>Corynebacterium</italic>. Important concepts associated with virulence highlighting the role of Pld protein and Tox gene. The adhesion, characteristic of virulence factor, was described using the sortase mechanism that is associated to anchorage to the cell wall. In addition, survival inside the host cell and some diseases, were too addressed for pathogenic corynebacteria, while important biochemical pathways and biotechnological applications retain the focus of this review for non-pathogenic corynebacteria. Concluding, this review broadly explores characteristics in genus <italic>Corynebacterium</italic> showing to have strong relevance inside the medical, veterinary, and biotechnology field.</p>