AUTHOR=Yu Yang , Fang Jin-Tao , Sun Jian , Zheng Mei , Zhang Qing , He Jie-Shun , Liao Xiao-Ping , Liu Ya-Hong 

TITLE=Efficacy of Cefquinome against Escherichia coli Environmental Mastitis Assessed by Pharmacokinetic and Pharmacodynamic Integration in Lactating Mouse Model

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 8 - 2017

YEAR=2017

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.01445

DOI=10.3389/fmicb.2017.01445

ISSN=1664-302X

ABSTRACT=<p>This work investigates the pharmacodynamic effectiveness of cefquinome against environmental <italic>Escherichia coli</italic> mastitis infection, following an intramammary administration. We established the pharmacokinetic and pharmacodynamic (PK/PD) model in lactating mice. The PK/PD parameters were identified to achieve an antibacterial efficacy as indicated by PD activity, cytokine expression and PK/PD simulation. From our findings, given an 200 μg/gland dose once daily can achieve a considerable therapeutic effectiveness in experimental circumstance.</p>