AUTHOR=Kamjam Manita , Sivalingam Periyasamy , Deng Zinxin , Hong Kui 

TITLE=Deep Sea Actinomycetes and Their Secondary Metabolites

JOURNAL=Frontiers in Microbiology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.00760

DOI=10.3389/fmicb.2017.00760

ISSN=1664-302X

ABSTRACT=<p>Deep sea is a unique and extreme environment. It is a hot spot for hunting marine actinomycetes resources and secondary metabolites. The novel deep sea actinomycete species reported from 2006 to 2016 including 21 species under 13 genera with the maximum number from <italic>Microbacterium</italic>, followed by <italic>Dermacoccus, Streptomyces</italic> and <italic>Verrucosispora</italic>, and one novel species for the other 9 genera. Eight genera of actinomycetes were reported to produce secondary metabolites, among which <italic>Streptomyces</italic> is the richest producer. Most of the compounds produced by the deep sea actinomycetes presented antimicrobial and anti-cancer cell activities. Gene clusters related to biosynthesis of desotamide, heronamide, and lobophorin have been identified from the deep sea derived <italic>Streptomyces</italic>.</p>