AUTHOR=Bajpai Vivek K. , Shukla Shruti , Paek Woon K. , Lim Jeongheui , Kumar Pradeep , Na MinKyun 

TITLE=Antibacterial Action of Jineol Isolated from Scolopendra subspinipes mutilans against Selected Foodborne Pathogens

JOURNAL=Frontiers in Microbiology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.00552

DOI=10.3389/fmicb.2017.00552

ISSN=1664-302X

ABSTRACT=<p>This study was undertaken to assess the antibacterial potential of 3,8-dihydroxyquinoline (jineol) isolated from <italic>Scolopendra subspinipes mutilans</italic> against selected foodborne pathogens <italic>Escherichia coli</italic> O157:H7 and <italic>Staphylococcus aureus</italic> KCTC-1621. Jineol at the tested concentration (50 μL; corresponding to 250 μg/disk) exhibited significant antibacterial effects as a diameter of inhibition zones (11.6–13.6 mm), along with minimum inhibitory concentration (MIC) and minimum bactericidal concentration values found in the range of (62.5–125 μg/mL) and (125–250 μg/mL), respectively. Jineol also exhibited significant antibacterial effects as confirmed by the reduction in bacterial cell viabilities, increasing release of potassium (K<sup>+</sup>) ions (650 and 700 mmole/L) and 260 nm materials (optical density: 2.98–3.12) against both the tested pathogens, <italic>E. coli</italic> O157:H7 and <italic>S. aureus</italic> KCTC-1621, respectively. Moreover, changes in the cell wall morphology of <italic>E. coli</italic> O157:H7 and <italic>S. aureus</italic> KCTC-1621 cells treated with jineol at MIC further confirmed its inhibitory potential against the tested pathogens, suggesting its role as an effective antimicrobial to control foodborne pathogens.</p>