AUTHOR=Pascapurnama Dyshelly N. , Labayo Hannah K. M. , Dapat Isolde , Nagarajegowda Divya D. , Zhao Jingge , Zhang Jing , Yamada Osamu , Kikuchi Haruhisa , Egawa Shinichi , Oshima Yoshiteru , Chagan-Yasutan Haorile , Hattori Toshio TITLE=Induction of Osteopontin by Dengue Virus-3 Infection in THP-1 Cells: Inhibition of the Synthesis by Brefelamide and Its Derivative JOURNAL=Frontiers in Microbiology VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.00521 DOI=10.3389/fmicb.2017.00521 ISSN=1664-302X ABSTRACT=
Osteopontin (OPN) is a multifunctional matricellular protein produced by a broad range of cells including osteoclasts, macrophages, T cells, endothelial cells, and vascular smooth muscle cells. OPN modulates various physiological and pathological events such as inflammation, wound healing, and bone formation and remodeling. Dengue virus (DENV) infection causes an increase in plasma OPN levels, which is correlated with the severity of symptoms and coagulation abnormalities. DENV infection also induces