AUTHOR=de Oliveira Sandra R. P. , Nomizo Auro , Frantz Fabiani G. , Faccioli Lúcia H. , Matos Ana Paula Keller de , Carrilho Emanuel , Afonso Ana , de Freitas Anibal Fernanda 

TITLE=Participation of Leukotrienes in the Immune Modulation of Oral Tolerance

JOURNAL=Frontiers in Microbiology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.00242

DOI=10.3389/fmicb.2017.00242

ISSN=1664-302X

ABSTRACT=<p>Oral tolerance (OT) is characterized as a peripheral immune tolerance form, in which, mature lymphocytes in lymphoid tissues associated with mucosa, become non-functional or hypo responsive due to prior oral administration of antigen. OT is an important immunological phenomenon due to its therapeutic potential in inflammatory processes and others diseases. Here we evaluated leukotriene role in the induction of OT, as well as, the production of cytokines IL-5 and IFN-γ in leukotriene deficient animals (knock-out). Our results suggested that even in the presence of OT and leukotrienes absence, cytokine IFN-γ remains being secreted, which gives us an indication of immune system specificity and also that IFN-γ participates in various immune processes.</p>