AUTHOR=Portugal Brina , Motta Flávia N. , Correa Andre F. , Nolasco Diego O. , de Almeida Hugo , Magalhães Kelly G. , Atta Ana L. V. , Vieira Francisco D. , Bastos Izabela M. D. , Santana Jaime M. TITLE=Mycobacterium tuberculosis Prolyl Oligopeptidase Induces In vitro Secretion of Proinflammatory Cytokines by Peritoneal Macrophages JOURNAL=Frontiers in Microbiology VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.00155 DOI=10.3389/fmicb.2017.00155 ISSN=1664-302X ABSTRACT=
Tuberculosis (TB) is a disease that leads to death over 1 million people per year worldwide and the biological mediators of this pathology are poorly established, preventing the implementation of effective therapies to improve outcomes in TB. Host–bacterium interaction is a key step to TB establishment and the proteases produced by these microorganisms seem to facilitate bacteria invasion, migration and host immune response evasion. We presented, for the first time, the identification, biochemical characterization, molecular dynamics (MDs) and immunomodulatory properties of a prolyl oligopeptidase (POP) from