AUTHOR=Rukasha Ivy , Said Halima M. , Omar Shaheed V. , Koornhof Hendrik , Dreyer Andries W. , Musekiwa Alfred , Moultrie Harry , Hoosen Anwar A. , Kaplan Gilla , Fallows Dorothy , Ismail Nazir TITLE=Correlation of rpoB Mutations with Minimal Inhibitory Concentration of Rifampin and Rifabutin in Mycobacterium tuberculosis in an HIV/AIDS Endemic Setting, South Africa JOURNAL=Frontiers in Microbiology VOLUME=7 YEAR=2016 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2016.01947 DOI=10.3389/fmicb.2016.01947 ISSN=1664-302X ABSTRACT=
Treatment of tuberculosis (TB) and HIV co-infections is often complicated by drug-to-drug interactions between anti-mycobacterial and anti-retroviral agents. Rifabutin (RFB) is an alternative to rifampin (RIF) for TB regimens and is recommended for HIV patients concurrently receiving protease inhibitors because of reduced induction of CYP3A4. This study sought to determine the proportion of RFB susceptible isolates among RIF-resistant strains in a high HIV prevalence setting in South Africa. In addition, the study explored the association between