AUTHOR=Singh Anurag , Lelis Felipe , Braig Stefanie , Schäfer Iris , Hartl Dominik , Rieber Nikolaus 

TITLE=Differential Regulation of Myeloid-Derived Suppressor Cells by Candida Species

JOURNAL=Frontiers in Microbiology

VOLUME=7

YEAR=2016

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2016.01624

DOI=10.3389/fmicb.2016.01624

ISSN=1664-302X

ABSTRACT=<p>Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterized by their ability to suppress T-cell responses. Recently, we demonstrated that the human-pathogenic fungi <italic>Candida albicans</italic> and <italic>Aspergillus fumigatus</italic> induced a distinct subset of neutrophilic MDSCs. To dissect <italic>Candida</italic>-mediated MDSC induction in more depth, we studied the relative efficacy of different pathogenic non-<italic>albicans Candida</italic> species to induce and functionally modulate neutrophilic MDSCs, including <italic>C. glabrata, C. parapsilosis, C. dubliniensis</italic>, and <italic>C. krusei</italic>. Our data demonstrate that the extent of MDSC generation is largely dependent on the <italic>Candida</italic> species with MDSCs induced by <italic>C. krusei</italic> and <italic>C. glabrata</italic> showing a higher suppressive activity compared to MDSCs induced by <italic>C. albicans.</italic> In summary, these studies show that fungal MDSC induction is differentially regulated at the species level and differentially affects effector T-cell responses.</p>