AUTHOR=Prieto-Davó Alejandra , Dias Tiago , Gomes Sofia E. , Rodrigues Sara , Parera-Valadez Yessica , Borralho Pedro M. , Pereira Florbela , Rodrigues Cecilia M. P. , Santos-Sanches Ilda , Gaudêncio Susana P. TITLE=The Madeira Archipelago As a Significant Source of Marine-Derived Actinomycete Diversity with Anticancer and Antimicrobial Potential JOURNAL=Frontiers in Microbiology VOLUME=7 YEAR=2016 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2016.01594 DOI=10.3389/fmicb.2016.01594 ISSN=1664-302X ABSTRACT=
Marine-derived actinomycetes have demonstrated an ability to produce novel compounds with medically relevant biological activity. Studying the diversity and biogeographical patterns of marine actinomycetes offers an opportunity to identify genera that are under environmental pressures, which may drive adaptations that yield specific biosynthetic capabilities. The present study describes research efforts to explore regions of the Atlantic Ocean, specifically around the Madeira Archipelago, where knowledge of the indigenous actinomycete diversity is scarce. A total of 400 actinomycetes were isolated, sequenced, and screened for antimicrobial and anticancer activities. The three most abundant genera identified were