AUTHOR=Shahmirzadi Shideh V. , Nguyen Minh-Thu , Götz Friedrich 

TITLE=Evaluation of Staphylococcus aureus Lipoproteins: Role in Nutritional Acquisition and Pathogenicity

JOURNAL=Frontiers in Microbiology

VOLUME=7

YEAR=2016

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2016.01404

DOI=10.3389/fmicb.2016.01404

ISSN=1664-302X

ABSTRACT=<p>Bacterial lipoproteins (Lpp) represent a major class of membrane proteins. They are distinguished by a lipid moiety at the N-terminus by which they are anchored either in the outer leaflet of the cytoplasmic membrane or, in Gram-negative bacteria, also in the inner leaflet of the outer membrane. In Gram-positive bacteria Lpp significantly contribute to nutrient transport, Toll-like receptor 2 activation and pathogenicity. Here we examine the Lpp of <italic>Staphylococcus aureus</italic> USA300, as a prototype for a multiple antibiotic resistant and community-acquired pathogen that is rapidly spreading worldwide. The compiled Lpp were grouped according to the postulated function and dissemination of homologs in the genus <italic>Staphylococcus</italic> and beyond. Based on this evaluation we also point out Lpp as promising vaccine candidates.</p>