AUTHOR=Ktsoyan Zhanna A. , Mkrtchyan Mkhitar S. , Zakharyan Magdalina K. , Mnatsakanyan Armine A. , Arakelova Karine A. , Gevorgyan Zaruhi U. , Sedrakyan Anahit M. , Hovhannisyan Alvard I. , Arakelyan Arsen A. , Aminov Rustam I. TITLE=Systemic Concentrations of Short Chain Fatty Acids Are Elevated in Salmonellosis and Exacerbation of Familial Mediterranean Fever JOURNAL=Frontiers in Microbiology VOLUME=7 YEAR=2016 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2016.00776 DOI=10.3389/fmicb.2016.00776 ISSN=1664-302X ABSTRACT=
Gut microbiota-produced short chain fatty acids (SCFAs) play an important role in the normal human metabolism and physiology. Although the gradients of SCFAs from the large intestine, where they are largely produced, to the peripheral blood as well as the main routes of SCFA metabolism by different organs are known well for the healthy state, there is a paucity of information regarding how these are affected in disease. In particular, how the inflammation caused by infection or autoinflammatory disease affect the concentration of SCFAs in the peripheral venous blood. In this work, we revealed that diseases caused either by infectious agents (two