AUTHOR=Radoshevich Lilliana , Dussurget Olivier 

TITLE=Cytosolic Innate Immune Sensing and Signaling upon Infection

JOURNAL=Frontiers in Microbiology

VOLUME=7

YEAR=2016

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2016.00313

DOI=10.3389/fmicb.2016.00313

ISSN=1664-302X

ABSTRACT=<p>Cytosolic sensing of pathogens is essential to a productive immune response. Recent reports have emphasized the importance of signaling platforms emanating from organelles and cytosolic sensors, particularly during the response to intracellular pathogens. Here, we highlight recent discoveries identifying the key mediators of nucleic acid and cyclic nucleotide sensing and discuss their importance in host defense. This review will also cover strategies evolved by pathogens to manipulate these pathways.</p>