AUTHOR=Smeekens S. P. , van de Veerdonk F. L. , Netea M. G. 

TITLE=An Omics Perspective on Candida Infections: Toward Next-Generation Diagnosis and Therapy

JOURNAL=Frontiers in Microbiology

VOLUME=7

YEAR=2016

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2016.00154

DOI=10.3389/fmicb.2016.00154

ISSN=1664-302X

ABSTRACT=<p><italic>Candida</italic> species can cause severe infections associated with high morbidity and mortality. Therefore, it is essential to gain more insight into the anti-fungal host defense response. The advent of <italic>omics</italic> technology and development of advanced systems biology tools has permitted to approach this in an unbiased and quantitative manner. This review summarizes the insights gained on anti-<italic>Candida</italic> immunity from genetic-, transcriptome-, proteome-, metabolome-, microbiome-, mycobiome-, and computational systems biology studies and discusses practical aspects and future perspectives.</p>