AUTHOR=Solórzano Carla , Srikumar Shabarinath , Canals Rocío , Juárez Antonio , Paytubi Sonia , Madrid Cristina TITLE=Hha has a defined regulatory role that is not dependent upon H-NS or StpA JOURNAL=Frontiers in Microbiology VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2015.00773 DOI=10.3389/fmicb.2015.00773 ISSN=1664-302X ABSTRACT=
The Hha family of proteins is involved in the regulation of gene expression in enterobacteria by forming complexes with H-NS-like proteins. Whereas several amino acid residues of both proteins participate in the interaction, some of them play a key role. Residue D48 of Hha protein is essential for the interaction with H-NS, thus the D48N substitution in Hha protein abrogates H-NS/Hha interaction. Despite being a paralog of H-NS protein, StpA interacts with HhaD48N with higher affinity than with the wild type Hha protein. To analyze whether Hha is capable of acting independently of H-NS and StpA, we conducted transcriptomic analysis on the