AUTHOR=Kim Jong-Chul , Oh Euna , Kim Jinyong , Jeon Byeonghwa 

TITLE=Regulation of oxidative stress resistance in Campylobacter jejuni, a microaerophilic foodborne pathogen

JOURNAL=Frontiers in Microbiology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2015.00751

DOI=10.3389/fmicb.2015.00751

ISSN=1664-302X

ABSTRACT=<p><italic>Campylobacter jejuni</italic> is one of the leading bacterial causes of human gastroenteritis. Due to the increasing rates of human campylobacteriosis, <italic>C. jejuni</italic> is considered as a serious public health concern worldwide. <italic>C. jejuni</italic> is a microaerophilic, fastidious bacterium. <italic>C. jejuni</italic> must overcome a wide range of stress conditions during foodborne transmission to humans, such as food preservation and processing conditions, and even in infection of the gastrointestinal tracts of humans. Particularly, this microaerophilic foodborne pathogen must survive in the atmospheric conditions prior to the initiation of infection. <italic>C. jejuni</italic> possesses unique regulatory mechanisms for oxidative stress resistance. Lacking OxyR and SoxRS that are highly conserved in other Gram-negative foodborne pathogens, <italic>C. jejuni</italic> modulates the expression of genes involved in oxidative stress resistance mainly via the peroxide resistance regulator and <italic>Campylobacter</italic> oxidative stress regulator. Based on recent findings of ours and others, in this review, we described how <italic>C. jejuni</italic> regulates the expression of oxidative stress defense.</p>