AUTHOR=Matsumoto Kouji , Hara Hiroshi , Fishov Itzhak , Mileykovskaya Eugenia , Norris Vic 

TITLE=The membrane: transertion as an organizing principle in membrane heterogeneity

JOURNAL=Frontiers in Microbiology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2015.00572

DOI=10.3389/fmicb.2015.00572

ISSN=1664-302X

ABSTRACT=<p>The bacterial membrane exhibits a significantly heterogeneous distribution of lipids and proteins. This heterogeneity results mainly from lipid–lipid, protein–protein, and lipid–protein associations which are orchestrated by the coupled transcription, translation and insertion of nascent proteins into and through membrane (transertion). Transertion is central not only to the individual assembly and disassembly of large physically linked groups of macromolecules (<italic>alias</italic> hyperstructures) but also to the interactions between these hyperstructures. We review here these interactions in the context of the processes in <italic>Bacillus subtilis</italic> and <italic>Escherichia coli</italic> of nutrient sensing, membrane synthesis, cytoskeletal dynamics, DNA replication, chromosome segregation, and cell division.</p>