AUTHOR=Hepojoki Jussi , Vaheri Antti , Strandin Tomas 

TITLE=The fundamental role of endothelial cells in hantavirus pathogenesis

JOURNAL=Frontiers in Microbiology

VOLUME=5

YEAR=2014

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2014.00727

DOI=10.3389/fmicb.2014.00727

ISSN=1664-302X

ABSTRACT=<p><italic>Hantavirus,</italic> a genus of rodent- and insectivore-borne viruses in the family <italic>Bunyaviridae</italic>, is a group of emerging zoonotic pathogens. Hantaviruses cause hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome in man, often with severe consequences. Vascular leakage is evident in severe hantavirus infections, and increased permeability contributes to the pathogenesis. This review summarizes the current knowledge on hantavirus interactions with hematopoietic and endothelial cells, and their effects on the increased vascular permeability.</p>