AUTHOR=Ciminale Vincenzo , Rende Francesca , Bertazzoni Umberto , Romanelli Maria G. 

TITLE=HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties

JOURNAL=Frontiers in Microbiology

VOLUME=5

YEAR=2014

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2014.00398

DOI=10.3389/fmicb.2014.00398

ISSN=1664-302X

ABSTRACT=<p>HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization and expression pattern, but they differ substantially in their pathogenic properties. This review outlines distinctive features of HTLV-1 and HTLV-2 that might provide clues to explain their distinct clinical outcomes. Differences in the kinetics of viral mRNA expression, functional properties of the regulatory and accessory proteins, and interactions with cellular factors and signal transduction pathways are discussed.</p>