AUTHOR=Avdic Selmir , McSharry Brian P. , Slobedman Barry 

TITLE=Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus

JOURNAL=Frontiers in Microbiology

VOLUME=5

YEAR=2014

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2014.00337

DOI=10.3389/fmicb.2014.00337

ISSN=1664-302X

ABSTRACT=<p>Human cytomegalovirus (HCMV), a clinically important β-herpesvirus, is a master of evasion and modulation of the host immune system, including inhibition of a number of dendritic cell (DC) functions. DCs play a central role in co-ordination of the immune response against pathogens and any disturbance of DCs functions can result in a cascade effect on a range of immune cells. Recently, the HCMV gene <italic>UL111A</italic>, which encodes viral homologs of human interleukin 10, has been identified as a strong suppressor of a number of DCs functions. In this mini review, we focus on HCMV-encoded viral IL-10-mediated inhibitory effects on DCs and implications for the development of an effective HCMV vaccine.</p>