AUTHOR=Cloeckaert Axel 

TITLE=ramR mutations affecting fluoroquinolone susceptibility in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198

JOURNAL=Frontiers in Microbiology

VOLUME=4

YEAR=2013

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2013.00213

DOI=10.3389/fmicb.2013.00213

ISSN=1664-302X

ABSTRACT=<p>A screening for non-target mutations affecting fluoroquinolone susceptibility was conducted in epidemic multidrug-resistant <italic>Salmonella enterica</italic> serovar Kentucky ST198. Among a panel of representative isolates (<italic>n</italic> = 27), covering the epidemic, only three showed distinct mutations in <italic>ramR</italic> resulting in enhanced expression of genes encoding the AcrAB-TolC efflux system and low increase in ciprofloxacin MIC. No mutations were detected in other regulatory regions of this efflux system. Ciprofloxacin resistance in serovar Kentucky ST198 is thus currently mainly due to multiple target gene mutations.</p>