AUTHOR=Green Keith , Garneau-Tsodikova Sylvie 

TITLE=Resistance in tuberculosis: what do we know and where can we go?

JOURNAL=Frontiers in Microbiology

VOLUME=4

YEAR=2013

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2013.00208

DOI=10.3389/fmicb.2013.00208

ISSN=1664-302X

ABSTRACT=<p>Tuberculosis (TB) has become a worldwide threat, mainly due to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of <italic>Mycobacterium tuberculosis</italic> (<italic>Mtb</italic>). This mini-review is focused on the various mechanisms of resistance to the currently available anti-TB drugs and provides perspective on novel strategies and lead scaffolds/compounds aimed at inhibiting/overcoming these resistance mechanisms.</p>