AUTHOR=Taguchi Fumihiro , Hirai-Yuki Asuka 

TITLE=Mouse Hepatitis Virus Receptor as a Determinant of the Mouse Susceptibility to MHV Infection

JOURNAL=Frontiers in Microbiology

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2012.00068

DOI=10.3389/fmicb.2012.00068

ISSN=1664-302X

ABSTRACT=<p>In this review, we report that the receptor of mouse hepatitis virus (MHV), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), is an important determinant of mouse susceptibility to MHV infection. This finding was revealed by using mouse strains with two different allelic forms of the MHV receptor, <italic>Ceacam1a</italic> and <italic>Ceacam1b</italic>. Although previous studies indicated that susceptibility is determined by a single gene, <italic>Ceacam1</italic>, our recent work in gene-replaced mice with chimeric <italic>Ceacam1</italic> pointed toward the involvement of other host factors (genes) in the susceptibility. Studies on mouse susceptibility to MHV, as well as the factors involved in their susceptibility, are overviewed.</p>