AUTHOR=van Hoek Angela H., Mevius Dik , Guerra Beatriz , Mullany Peter , Roberts Adam P., Aarts Henk J. TITLE=Acquired Antibiotic Resistance Genes: An Overview JOURNAL=Frontiers in Microbiology VOLUME=2 YEAR=2011 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2011.00203 DOI=10.3389/fmicb.2011.00203 ISSN=1664-302X ABSTRACT=

In this review an overview is given on antibiotic resistance (AR) mechanisms with special attentions to the AR genes described so far preceded by a short introduction on the discovery and mode of action of the different classes of antibiotics. As this review is only dealing with acquired resistance, attention is also paid to mobile genetic elements such as plasmids, transposons, and integrons, which are associated with AR genes, and involved in the dispersal of antimicrobial determinants between different bacteria.